To our knowledge, the present study is the first to assess DAT binding in the partially 6-OHDA-lesioned rat, using small-animal SPECT/CT imaging.
In the present feasibility study, we established an experimental protocol to evaluate brain metabolism during volume-induced voiding and isovolumetric bladder contractions in anaesthetized rats using small-animal PET brain imaging with the aim of providing a basis for further PET-based research in this field.
We can conduct rat experiments using small amounts of drugs, due to the animal's low body weight.
To investigate the effects of VDR down-regulation in some of the neurodegeneration-related mechanisms, VDR was knocked down in cultured rat cortical neurons using small interfering RNA (siRNA) induced gene silencing.
We present a non-invasive, entirely image-based method to assess AR in an allogeneic rat renal transplantation model using small animal positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG).
RATest: Explaining Wrong Queries Using Small Examples.
"RATest: explaining wrong relational queries using small examples". In Proceedings of the 2019 ACM SIGMOD International Conference on Management of Data, Amsterdam, Netherlands, June 2019.
In a transcriptomic and proteomic analysis performed using small samples of rat spinal cord, it was shown that although providing similar RNA recovery yield, the protein recovery yield can be increased by processing samples using AFD followed by protein extraction using TRIzol®, as compared to direct sample homogenization in TRIzol®[ 4].
The total RNA and miRNA fractions were isolated from the livers of control and biotin-supplemented rats using a small RNA isolation kit (Ambion, CA, USA).
It has been suggested, albeit using smaller datasets, that the rat and dog data may perform equally well.
The most widely used small animal model in neurourological research is the rat.
