At 4 and 6 weeks after oxaliplatin administration, sensory threshold values were significantly decreased and at 6 weeks after oxaliplatin administration, thermal threshold values were significantly increased in oxaliplatin-treated rats compared with those in rat treated with oxaliplatin and green tea extracts.
b Section in rat treated with CP showing leucocytic infiltration (yellow arrow).
Fig. 3 Photomicrograph of liver section from a rat treated with four times the clinical dose of AS-AQ.
e Section in rat treated with ABG and CP showing marked improvement of hepatic tissue with normal hepatocytes (arrows) radiating around central vein (cv).
c Sections in rat treated with ABG + CP showing marked improvement of DNA content with increasing number of nuclei (Feulgen histochemical stain, × 400).
Based on this study, the rat treated with bisphosphonates and steroids can be considered a novel, reliable and reproducible model to understand pathology of BRONJ.
Based on this study, the rat treated with bisphosphonates and steroids can be considered a novel, reliable and reproducible model to understand better pathology of BRONJ.
c Hepatocyte of rat treated with ABG + CP showing improvement in DNA and reduction of damaged spots (bromide ethidium staining, × 400).
The target antigen detected in a tumor treated with unlabeled BR96 (A), a tumor treated with 2.5 MBq 211At-BR96 (B), an abdominal metastasis in a rat treated with 2.5 MBq 211At-BR96 (C), and a lymph node metastasis in a rat treated with 5 MBq 211At-BR96 (D).
In thermal imaging, decreased temperature was observed in rat treated with fungal and authentic taxol when compared to tumor induced rats.
However, hepatic histopathological sections of the rat treated with high doses of BPA have increased inflammatory cells, distended blood sinusoids, and vacuolized swollen hepatocytes, with pyknotic nuclei (Fig. 1c, d).
