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On session one only, all three arms were open for the rat to select.
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We first evaluated the dose response relationship for amphetamine in inducing hyperlocomotion in rats to select an optimal dose for subsequent reversal studies with VU0467154.
This learning deficit was reflected in the failure of the ATNx1 rats to select preferentially the correct corners on the first swim trial after passive training or to prefer the vicinity of the correct corners over the incorrect corners when allowed to swim around the rectangular pool (Probe Test, Experiment 1).
It was predicted that amphetamine would disrupt rats' ability to select appropriately the most valid CSs for learning which would be expressed as increased conditioning to weaker, 50% valid CSs.
During choice, each trial began with the simultaneous presentation of both levers S and C. Rats had to select one of the two levers.
In Experiment 2 (alternating black and white walls), the ATNx2 rats failed to select the correct corner first on the initial probe test after passive training.
After 3 blocks (30 trials), the majority of rats continued to select the HR arm and therefore had received very little exposure to the new contingencies in the LR arm (i.e., that the delay had been removed from this arm).
During the 1st three blocks of testing in stage 3 (30 trials), the majority of rats continued to select the HR arm and therefore received very little exposure to the new contingencies in the LR arm (i.e., that reward was no longer delayed in this arm).
Xiong's group use "arthritis" together with a rat gene symbol to select references from PubMed and OMIM, whereas we use the same term to assign values to 49 preselected keywords [ 8].
Rats were trained to select an odor that they had not previously encountered within the current session, and the number of odors to remember was incremented up to 24 during the course of each session.
The rats were allowed to select their thermal environment by freely moving in a thermogradient apparatus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com