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Applying the model of the naked mole rat to human cancer resistance is unlikely to be as simple as upregulating existing anticancer genes.
This SNP replaces a serine with an asparagine at amino acid residue 306 (S306N) in the LIVBP domain of GRIA1, which is highly conserved from rat to human (Figure 2, Panel C).
These findings are consistent with our previous studies of transplanting specific subtypes of rodent glial precursor derived astrocytes into sites of spinal cord injury, and indicate a remarkable conservation from rat to human of functional differences between astrocyte subtypes.
Hence, translating data from rat to human would have at least flagged this issue.
This provides the opportunity to replace rat biological system parameters by human values, and to provide an extrapolation step from rat to human.
To the Editor: Kurth et al (1 ) recently described a cowpoxvirus chain of transmission from rat to human through an elephant in Germany.
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Pinker goes even further by drawing a straight line from those blissed-out rats to human mothers who dial back at work.
The susceptibility of rats to human HEV genotypes is controversial.
We thus transformed the significantly changed proteins with diuretic administration in rats to human orthologs.
Recently, rat-to-elephant and rat-to-human CPXV transmission were described [29], [30], on the basis of the perfect homology of the ha gene open reading frame (ORF) of CPXV isolates from distinct hosts.
Our case is the first proven rat-to-human transmission of cowpox.
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