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This model has been extensively characterized in the rat to clarify mechanisms underlying denervation-induced gliosis, transneuronal degeneration of denervated neurons, and collateral sprouting of surviving axons.
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This study has evaluated minocycline influence on expression of Aβ protein, tau phosphorylation, and inflammatory cytokines (interleukin-1β and tumor necrosis factor-α) in the brain of diabetic rats to clarify neuroprotection by minocycline under diabetic metabolic disorder.
Our study aimed to investigate the role of CCL2/CCR2 in Nav1.8 modulation in rat DRG, to clarify whether the regulation of CCL2 on Nav1.8 is dependent on PKC activation, and to make determine if the NF-κB (nuclear factor κB) pathway is involved in the regulation of Nav1.8 expression.
The present study was designed to establish biochemical and histological differences in Cd toxicity in WI and Fischer rats, and to clarify the mechanistic basis of these strain differences.
The present experiment in rats was designed to clarify whether partial liver irradiation could induce and stimulate the unirradiated part of liver to regenerate.
PET studies with [11C]flumazenil in epileptic rats are needed to clarify whether local changes in cerebral [11C]flumazenil uptake in epilepsy are due to decreased GABA-ergic function, P-gp upregulation, or both.
Many studies in humans and in rat models have been conducted to clarify the relationship between oxidative stress and antioxidants in the liver.
The objective of this study was to identify the key TLR in pristane-induced arthritis (PIA), a rat model for RA, and to clarify its roles in the initiation and maintenance of arthritis.
Longitudinal field studies are required to clarify if rats could be the principal reservoirs for CPXV.
Given the absence of 'hallmark' striatal atrophy in transgenic HD rats, further investigations are warranted to clarify the relevance of the model for striatal degeneration in HD patients.
Figure 5 shows the 3d surface rendering of the main components from the mice (40 comp. ICA) and rat (15 comp. ICA) rsfMRI to clarify their approximate mutual localization.
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