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Nonetheless, our results show that in the normal rat, the expression of p38 MAPK is low and does not change following a LAD ligation or with losartan therapy (Fig 3).
Sabolić and coworkers (Sabolic et al., 2006) showed that, in castrated rat, the expression of SGLTs is exclusively affected by androgens, whereas E2 and progesterone have no effect.
Recently, in an animal model of ADHD (using the spontaneously hypertensive rat), the expression of specific genes involved in dopamine neuron differentiation and functioning during the postnatal development of the midbrain was studied [ 51].
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In rats, the expression of P-gp is approximately 4 times higher than that of Bcrp (ABCG2) and 12 times higher than that of Mrp4 (ABCC4) [7].
Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was to evaluate in the myocardium of CsA-treated rats the expression variations of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 2 (MMP2), to verify if: VEGF increased, VEGF increase was associated with MMP2 increase and they could be considered as repair proteins.
Compared to the control rats, the expression level of LC3 was higher in chondrocytes of the cartilage obtained from OA model rats (Fig. 8A).
In rats, the expression of HMGCS2 in the colon depends on the amount of butyrate produced by the intestinal microbiota [49], [50].
In DA rats the expression was induced to twice the level of PVG and a hundred-fold compared to the naïve (Figure 5G).
In rats, the expression of the mRNA was 4-folds higher in young male animals than in old ones (p = 0.0022, Figure 5B).
In rats, the expression of ε subunits is associated with peptidergic neurons, such as those producing orexin, oxytocin, and gonadotropin-releasing hormone (GnRH).
During the first two postnatal weeks in rats, the expression of the GluR2 subunit-containing AMPARs are increased in the CA1 region [90], leading to attenuated Ca2+ influx, since this subunit exhibits low permeability to Ca2+ [94].
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