Sentence examples for rat strains such from inspiring English sources
Thus, a natural cytotoxic activity against mouse ES cells exists not only in LOU/c rats but also in other rat strains such as DA and LEW.1N.
Arthritis can be induced in susceptible rat strains such as Dark Agouti (DA) or Lewis by a single intradermal injection of the chemically inert mineral oil pristane.
Previous studies have demonstrated that Long-Evans rats alter their gestation length when treated with pro-inflammatory agents [ 23], whilst other rat strains such as the Sprague-Dawley does not appear to respond accordingly [ 24].
Adjuvant arthritis (AA) is inducible in susceptible rat strains, such as the Lewis (LEW) rat, by a single subcutaneous injection of heat-killed Mycobacterium tuberculosis H37Ra (Mtb) in oil.
Other rat strains, such as the Sprague-Dawley and Wistar Han, have a lower spontaneous incidence of Leydig cell tumors (∼ 5%), making them potentially more sensitive models (NTP 2005a).
In the WKY rat, a single injection of nephrotoxic serum (NTS) leads to proteinuria, glomerular macrophage infiltration and glomerular crescent formation in 90% of glomeruli with progression to severe scarring with renal failure by week 6 (Behmoaras et al., 2008; Cook et al., 1999; Tam et al., 1999), whereas rat strains such as Lewis (LEW) and Brown Norway are resistant.
Rat tumour cell lines are less common than murine tumour lines, but there are several known belonging to inbred laboratory rat strains (Rattus norwegicus) such as Wistar, Lewis, Sprague Dawley, Fischer 344 etc. Subcutaneous tumours differ in their rate of growth, degree of vascularization, amount and kind of tumour stroma and potential to form spontaneous metastasis.
In contrast, MPH elicits locomotor sensitization in non-hyperactive rat strains, whereas it has no such effect in SHRs [ 98].
Intercrosses of such susceptible rat strains with resistant strains are used for establishing linkage between genetic markers and quantitative traits distinguishing the arthritis phenotype.
Inbred strains such as F344 rats, which are frequently used in these experiments, are relatively uniform and the tumors developing after induction show phenotypic and genotypic features similar to those observed in human sporadic colon cancers, notably activation of Wnt signaling pathway and mutations in Kras and Apc genes [ 2].
We previously reported that Wistar Imamichi (WI) rats have a strong resistance to cadmium (Cd -induced lethality Cd -induced other strains such as Fischer 344 (Fischer) rats.
