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A linear dose response relationship was also observed in both rat strains after iv injection of graded doses (10iu to 10iu) of vectors encoding the marker genes luciferase and LacZ (data not shown).
As our primary hypothesis was to investigate the role of mitochondrial oxidative stress and determine how gene expression patterns differ between two rat strains after DE exposure, and also because our findings of DE effects on gene expression are unexpected, we did not determine blood pressure in the present study.
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The anomaly observed in one F2 offspring following exposure of the F0 dam to 700 μg PBDE-47/kg on GD6 is one that we have never observed in our rat strain after examining > 10,100 fetuses (historical data).
In both rat strains the plasma levels reached a plateau after 3 days and remained constant for at least 1 month.
Most importantly, we provide experimental, biological evidence from Vra1 congenic rat strains that Vra1 regulates the degree of motoneuron degeneration after nerve injury.
As the first wave of round spermatids appears in rat testes around 26 days after birth, we estimate that congenic rat strains could be generated within 7 or 8 months by using these germ cells [21].
We have all these incredibly valuable rat strains that represent particular models of human disease, like hypertension or heart disease.
Pigmented rat strains have superior vision than albino rat strains and are therefore commonly used in visually-demanding cognitive tests.
We have examined two gene regions, Vra1 and Vra2, previously linked to nerve cell loss after ventral root avulsion in a rat F2 intercross between the DA and PVG inbred rat strains.
Rat strains are available upon request.
In three different rat strains bred from TCDD-resistant and -sensitive strains, circulating levels of testosterone were decreased 17 days after treatment with a single oral dose of 1,000 μg TCDD/kg BW (Simanainen et al. 2004a).
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