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The three months old male of Brown-Norway BN.lx rat strain was a gift from M. Pravenec and P. Mlejnek (Institute of Physiology, AS CR).
The BN/SsNSlc rat strain was purchased from Japan SLC (Hamamatsu, Japan).
The choice of the rat strain was made carefully so that it would contribute to the development of the model.
This established T2D rat strain was developed by selective breeding of more glucose intolerant Wistar (WIS) rats over 30 generations.
This rat strain was called by the International Rat Genetic Nomenclature Committee as the OXYS rat strain [ 30].
The LEW.W Crgn1,2 bicongenic rat strain was also resistant, showing no significant differences from the parental LEW strain in all three phenotypic disease parameters (Fig. 3A C).
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We propose that the F344 rat strain is particularly suited for the predictability assessment of novel anxiolytic drugs in both startle paradigms.
Thymidine concentrations determined in the plasma of 7 murine strains and one rat strain were between 0.61 ± 0.12 μM and 2.04 ± 0.64 μM, while the concentrations in 22 tumour models ranged from 0.54 ± 0.17 μM to 20.65 ± 3.65 μM.
The inbred Goto-Kakizaki (GK) rat strain is a unique model of spontaneous type 2 diabetes mellitus caused by naturally occurring genetic variants that have been selectively isolated from an outbred colony of Wistar rats.
Among the commonly used experimental rat strains, the Wistar Kyoto (WKY) rat strain is susceptible to induction of CRGN, whereas the Lewis (LEW) rat strain is resistant.
Copenhagen (COP) and Wistar- Kyoto (WKY) rat strains are resistant to DMBA, N-Nitroso- N-methylurea (NMU), and oncogene induced mammary carcinomas, while the Wistar- Furth (WF) rat strain is susceptible.
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