Sentence examples for rat plasma samples from inspiring English sources

Methotrexate and syringic acid (internal standard) were extracted from rat plasma samples by protein precipitation with acetonitrile.

Furthermore, the IEB has been successfully applied for biomonitoring of TCP in the rat plasma samples with in vivo exposure to organophosphorus insecticides like Chlorpyrifos-oxon (CPF-oxon).

Based on the analytical validation results, the proposed method (RAM-MIP off-line SPE/HPLC) can be a useful tool to determine 2-ME in rat plasma samples.

Fig. 2 Representative UHPLC MS/MS chromatograms of lesinurad and IS in rat plasma samples.

The rat plasma samples were treated via different methods for qualitative and quantitative analysis, respectively.

To liberate galangin from its glucuronides, some rat plasma samples were treated with β-glucuronidase.

a A blank plasma sample; b a blank plasma sample spiked with lesinurad and IS; c a rat plasma sample obtained 1 h after oral administration of lesinurad.

Figure 3 LC-MS/MS chromatograms for a typical blank rat plasma sample (panel A), the same blank plasma sample spiked with yakuchinone B (IS, panel B), a mixture of standard yakuchinone A and IS (panel C), and an IS-spiked plasma sample obtained from a rat 5 min after receiving a single oral dose of Suoquan capsules at 5.7 g/kg (panel D).

Typical LC MS/MS chromatograms of blank plasma, blank plasma spiked with lesinurad (50 ng/mL) and IS (200 ng/mL), and a rat plasma sample taken 1 h after oral administration of a single dose of 20 mg/kg lesinurad are shown in Fig. 2.

An aliquot of 2 μL of rat plasma sample was diluted 20-fold by PBS (100 mM, pH7.4) containing 0.5% SDS.

The selectivity of the method was evaluated by analyzing six different sources of blank rat plasma, blank plasma spiked with YH-8 at lower limit of quantification (LLOQ) and a rat plasma sample collected after oral administration of YH-8.