These findings, in addition to further elucidating signaling pathways that correlate with rat thyroid pathology, may provide useful biomarkers for the prediction of thyroid tumorigenesis after chronic exposure to xenobiotics in the rat.
Effects are a combination of study type, species, effect type, effect target, and effect description for a given chemical, for example, chronic/cancer, rat, neoplastic pathology, liver, and adenoma.
Sills, RC; Morgan, DL; Herr, DW; Little, PB; George, NM; Ton, TV; Love, NE; Maronpot, RR; Johnson, GA, Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats, Toxicologic Pathology, vol. 32 no. 5 (2004), pp. 501-510 [doi].
In the RCS rat, retinal vascular pathology develops as photoreceptors degenerate.
To establish whether deficits in DS astrocyte function could be involved in spine pathology, rat hippocampal neurons were cultured on top of NL or DS astrocyte monolayers (Figure 1A).
Only a few groups have characterized aspects of rat OA model pathology.
Nevertheless, further investigation will be needed to confirm the relationship between PP2A and CREB dephosphorylation in adult rat during heart pathology.
Animal model: Chemically induced renal tubular carcinoma in rats". American Journal of Pathology 100, no. 1 (1980): 317-320.
To model these aspects of the disease, we previously showed that high titer (5.1×10exp12 gp/ml) AAV1/2 driven expression of A53T α-syn in the SN of rats caused nigrostriatal pathology including a loss of DA neurons, but also with toxicity in the GFP control group.
Administration of the potent meprin inhibitor actinonin in rats prevents renal pathology, supporting the contribution of meprins to the pathogenesis of IR-induced renal injury [ 93, 94].
