MDMA was administered subcutaneously at 0 mg/kg (control), 0.5 mg/kg, 5 mg/kg and 10 mg/kg to SD male rats once a day, 3 consecutive days a week during 12 weeks, simulating human weekend associated consumption.
The researchers injected a synthetic version of the compound into more than 50 rats once a day for 2 weeks to mimic the effects of heavy, long-term marijuana use in people.
In the ulcerative colitis study, the same extract was administered orally (200 and 400 mg/kg) to rats once a day for 5 consecutive days and the last dose was administered 2 h before induction of colitis by intra-rectal infusion of acetic acid.
into HCC rats, once a week, at 20 mg/kg.
MeHg was administered intraperitoneally and DML was administered orally to 7-week-old rats once a day for 4 weeks.
Cd and/or DMS were administered orally to 7-week-old rats once a day for 4 weeks.
The reference drug, metformin (MET, 300 mg/kg), was also administered orally to the rats once a day.
One week prior to transplantation of tumour cells, we started to inject a LiCl solution into a group of eight Wistar Furth rats once a day.
In mice and rats, once a syntactic chain pattern begins with Phase I, each remaining action can be predicted with roughly 80 90% accuracy.
To investigate whether succinate causes cardiac hypertrophy, a succinate dose of 0.066 mg/kg, equivalent to that observed during ischemic events [ 15], was administered intravenously to rats, once a day, for 5 consecutive days.
