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Every rat of groups 3 and 4 received the amount of the liquid proportional to its body mass.
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For microarray analysis, 1 μg RNA from each rat of Group 1 was combined and 1 μg RNA from each rat of Group 2 was combined.
Subsequently, the rats of Groups 5 and 7 were staying at rest for four weeks whereas the rats of Groups 6 and 8 were exposed to chronic stressing.
Tumor development occurred only in rats of Groups 1 and 2, i.e. MNU exposed animals.
Tumors were not present in rats of Groups 3 and 4 (data not included in table).
The rats of Groups 2 and 4 were also exposed to mild chronic stressing.
The rats of groups 2 and 4 were housed individually to ensure the consumption of the entire dose of ASTA.
The plasma paracetamol levels were measured in rats of groups III and IV during the first 4 hours after administration.
Rats of Groups 4 (AND-treated group) as high dose were orally administrated with AND at a dose of 20 mg/kg daily for 12 weeks.
Rats of Groups 4 and 5 (treatment groups) were orally administrated with CLRE at daily doses of 250 mg/kg and 500 mg/kg, respectively.
Rats of groups II and IV were treated with CCl4 (2 ml/kg bwt) via the intraperitoneal route once a week for ten weeks.
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