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In the rat, not only is the elimination half-life of PFOA shorter than that in monkeys and humans, but a notable sex difference exists (Kemper 2003; Kudo et al. 2002; Vanden Heuval et al. 1991).
Moreover, the presence of this TFBS cluster in human Wnt5b, absent in that of the rodents (mouse and rat), not only explains the observed human-rodents divergence of Wnt5b promoters [ 42], but also agrees with its implication in human type 2 diabetes [ 43].
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Our results show that GBP, at a dose without enhanced effect on morphine's antinociception in naïve rats, not only potentiates morphine's antinociceptive effect in morphine-tolerant rats but also attenuates the development of morphine tolerance.
The lean rats not only ate junk for nine days and had a higher performance level, but they didn't gain.
In contrast, novel-setting exploration of the JS+EE rats not only was higher from JS rats but was also higher from Naïve rats.
For example, lactating rats not only show a profound suppression of pulsatile LH secretion, but also show a marked reduction in Kiss1 mRNA expression [31].
The UCD type 2 diabetic rats not only had reduced insulin sensitivity, but also had significantly more body mass.
Histological analysis of abdominal adipose tissue revealed increased immune cell accumulation in old rats not only in DIO rats, but also in control animals (Fig. 3A).
In addition, administration of low-dose dexamethasone to pregnant rats not only reduces birth weight but also leads to high blood pressure in young adult offspring [ 65].
In our work, we could also show significant changes between obese and lean rats not only in the subcutaneous fat, but also in the kidney and mesenterial fat.
Chronic exposure to FB1 in rats not only induced renal tumors, but also resulted in metastatic invasion of the lungs [ 136].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com