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To the best of our knowledge, these markers have not been evaluated in rat models where metabolic changes induced by sucrose ingestion are associated with liver damage caused by abnormalities in liver function.
Direct evidence for the ability of GHK-Cu to promote wound healing comes from experimental rat models where GHK treatment causes an acceleration of healing and a concentration-dependent increase of connective tissue and other ECM components [ 32, 33].
We therefore studied the effects of etanercept on tendon healing and endosteal membranous ossification in vivo using validated rat models, where the results of both of these processes can be tested mechanically.
This catecholamine hypotesis is also supported by the rat models, where Takostubo has been prevented with adrenergic blockade, by sampling of cardiac catecholamine levels in TCM [ 31] and by the reported cases in association with pheochromocytoma [ 32] and use of exogenous sympathomimetics.
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Plasma levels of carboxyfluorescein after oral MS administration proved a sustained release in a rat model, where Cmax of carboxyfluorescein solution was found at around 60 min while for MS formulations it was detected after 4 h.
From these results, an optimal rhBMP-2 eluting scaffold composition was selected and implanted in critical-sized calvarial defects in a rat model, where it demonstrated an excellent healing capacity in vivo.
Recent research works have demonstrated the efficacy of nanoparticle in a rat model where local analgesia was reported administered to nine of ten animals treated with bupivacaine-loaded nanofibers, with the effect of the LA been observed at day 1 and maximum effect observed at day 3; however, the observed effect was lost between 7 and 9 days.
For these studies we used the Vannucci H/I rat model where P6 rats are subjected to unilateral common carotid ligation followed by 75 min of systemic hypoxia.
Previously, we used a rat model where BDNF is infused in the dentate gyrus region of the hippocampal formation, and identified a panel of 14 genes that were up-regulated following BDNF treatment that induces long-term potentiation – LTP, in a similar way as the immediate early gene Arc [25].
We used a urethane anesthetized rat model, where 25 ml/kg of blood was withdrawn over 30 minutes.
This could have happened in our rat model, where histamine was injected into animals to induce inflammation.
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