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The calculated S values and the relative contributions to the mean absorbed dose to the inner follicle cell nuclei are presented in Table 2 with 123I, 125I and 131I homogeneously distributed within various source compartments (the follicle lumens and cells) in the human multiple thyroid follicle model (S values for the mouse and rat models, see Additional file 1).
In addition, region f showed a statistically significant difference (p < 0.01) between addicted and nonaddicted rat models (see f in Figure 4).
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It furthermore confirms in large part the OA-induced brain activity pattern previously found in the corresponding HAB/LAB rat model (see [13]).
Rat PLFs were obtained from the ICSS Wistar rat model (see below) accordingly.
For rats, plasma parameter estimates were fixed according to the best plasma model (see Table 3).
In monocrotaline-induced PH rat models, Cav1 deficiency is seen in lung tissue [ 19].
In rat models, relaxin decreases systemic vascular resistance (SVR) (see Fig. 3); [ 8] and stimulates greater decreases in SVR, when baseline SVR is high [ 8].
The F344 rat models some common sleep architecture and cognitive changes seen with age in humans, including the cognitively disrupting influence of active period deep sleep.
Recent data in a rat model showed that proteinuria seen in hyperthyroidism is not due podocyte pathology and that hyper- as well as hypothyroidism lead to an increased capillary density when compared to control animals while hyperthyroidism resulted in an expansion of glomerular area [ 53].
The 1990s saw a downturn in the development of rat models, as they became progressively overshadowed by the emerging transgenic mouse models of AD.
The beginning of the current decade saw an increasing number of preclinical studies using AD rat models characterized during the 2000s to implement drug development programs.
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