The results described above using the A β1-42-injected rat model represent correlated data between extents of microgliosis and viability of neurons.
Finally, the FRD rat model represents a valuable experimental tool to study the effect of agents potentially able to prevent or attenuate the vascular pathology associated with the MS and type 2 diabetes.
Advantages of a rat versus a mouse model include its size and evidence that the rat model may represent the human disease processes better than the mouse equivalent (Oyasu, 1995).
The paw swelling in AA rat model also represents the severity of arthritis.
To investigate the molecular and cellular pathogenesis underlying myocarditis, we used an experimental autoimmune myocarditis (EAM -induced hEAM -induced rat model theartepresents T cell mediated postinfailureoratheart disorders.
To this end, rat models of OA represent important translational research tools with which to investigate the pathophysiologic mechanisms of OA pain, and such models provide an opportunity for the investigation of CGRP-mediated pain mechanisms that cannot be achieved in humans.
These differences may reflect stages in disease progression in individual animals, with the larger responses (also seen in the GK rat model [ 8]) representing an early stage of compensatory upregulation of responsiveness.
The genetic dissection of a rat model for MS represents such an approach, with the assumption that there are conserved mechanisms regulating neuroinflammation among species.
After filtering against inclusion criteria 21 experimental settings were selected for meta-analysis and were represented by 11 rat models, 6 mouse models, and 2 models each for pig and human, with a total of 150 samples.
Genetic component of mammary cancer susceptibility is particularly obvious in the rat models, since different inbred strains, each representing a defined and limited gene pool, exhibit widely different susceptibility to both spontaneous and induced mammary cancer [ 7, 9, 10].
