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The evaluation of pulmonary surfactant assay was performed by a hysteresis curve drawn upon the measurement for the surface tension area curve with the Wilhelmy surface tensometer in vitro and the recovery of lung compliance for the pulmonary surfactant-deficient rat models in vivo.
In 2008, the team successfully visualized overexpressed c-MET in C6 (rat glioma) rat models in vivo by MRI based on a targeting contrast agent, anti-c-MET-Gd-DTPA-albumin, an anti-c-MET antibody linked to biotinylated Gd-DTPA-albumin [54].
At the seventh day after the diabetes rat models were prepared, the MSCs (5.0 × 106 cells/rat) labeled with QDs were injected into the rat models in the MSC treatment group via tail vein, while the normal control group rats received the same dose of QDs-labeled MSCs.
However, the use of rat models in mechanistic studies has been limited due to lack of genetically modified rat strains.
Lacosamide has also been analyzed in rat models in which pain is induced by systemic inflammation [ 13].
These can broadly be divided into rat models, in which elevated IOP is induced experimentally [ 33], and mouse models, where IOP elevation occurs spontaneously [ 18].
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Prior to its human clinical trials, its efficacy was tested in Zn induced HT Wistar rat model in the present study.
The study was aimed to illuminate the effect of chrysin in the pathogenesis of ammonium chloride (NH4Cl) induced hyperammonemic rat model in a dose dependent manner.
The therapeutic efficacy of the prepared nanospheres was assessed using the trinitrobenzenesulfonic acid (TNBS) colitis rat model, in comparison with conventional enteric microparticles.
Our results present the potential of inhibiting colon cancer in vitro and DMBA-induced tumor in rat model in vivo by liposomal celecoxib.
We used a new rat model in which major hepatectomy with I/R injury was performed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com