Sentence examples for rat models do from inspiring English sources
Historically, studies of burn in rat models do not usually account for the effects of disuse.
Previous work has shown that an acute exposure to LA in these rat models does not exacerbate inflammation despite increases in Fe-binding proteins and gene expression (Shannahan et al. 2011b).
A significant difference in the effectiveness of oral MBG-RCA and ME-RCA for eliminating colonic ammonia has not been shown in animal studies because the rat model did not include higher levels of ammonia production in the colon.
In line with several earlier investigations (Winkler et al. 2006; Blockx et al. 2011), we demonstrate that the transgenic HD rat model does not exhibit the hallmark basal ganglia atrophy seen in HD patients.
However, despite activating T cells against AQP4, these rat and mouse models do not develop a clinical neurological phenotype either because pathogenic T cells responses are limited by a combination of central and peripheral tolerance or because certain AQP4 epitopes are not pathogenic.
(Most models do, however).
However, while the dual PI3Kγ/δ inhibitor IP-145 could significantly reduce ankle swelling in a rat CIA model [ 30 ], it did not improve RA scores in a recent phase 2 clinical trial, showing that animal models do not always predict clinical outcomes in patients.
In animal studies, some models of psychosocial stress were able to induce hypertension in normotensive rats [ 132, 133], while other models did not produce changes in BP [ 134– 134].
First, as in other endotoxemic rat models, early treatment does not reflect the clinical situation [ 34].
For example, the rat rotator cuff model does not fully represent the anatomy, movement kinematics, or kinetics that exist in the human shoulder and rodents do not possess a homologue of the human MMP1 gene.
