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It is yet to be determined whether AICAR enhances insulin mediated MvP and thus glucose uptake in models of insulin resistance, such as the rat models described above.
Like the multidimensional rat models described above, this model recapitulates many features of human addiction, including price inelasticity or a willingness to work harder for the same amount of drug, punishment-resistant drug seeking and an increased preference for drug over alternative 'natural' rewards.
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To test this hypothesis, we studied adrenal endpoints of low-dose PBDE toxicity in our developmental subchronic exposure rat model described hereinabove [ 9].
In summary, the rat model described herein combined fracture, crush injury and infection with MRSA and ABC, resulting in greater limb perfusion but less bone vascularity in injured limbs than in uninjured limbs.
Using the Wistar Furth rat model described in their previous study [ 9], those investigators examined the expression pattern of p53 protein in response to hormonal stimulation and exposure to the chemical carcinogen methylnitroso urea (MNU) [ 17].
The construction of diabetic rat models is described in Materials and Methods.
We used the rat transplacental model described by Gómez-Meda et al., [ 16], which is based on exposing pregnant rats to the test agent from day 16 to 21 of gestation (the final stage of the organogenesis) in order to minimize toxicity to the developing fetuses.
The primary osteosarcoma was isolated from small tumor fragment of rat osteosarcoma model described above.
The clinical observations are in accordance with the report by Chen et al. (2004) using a rat model, who described how the increased fibroblast proliferation and biosynthesis of ECM and collagens, as well as the mechanical stress, are crucial for return to normal tendon strength.
In this study an mBSA-induced RA rat model was described with sustained and prolonged RA condition.
The modified ovalbumin (OVA) (Sigma-Aldrich, Beijing, China) inhalation method was used to generate the asthmatic rat model as described in detail elsewhere [ 8].
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