Sentence examples for rat model when from inspiring English sources

Then, we attenuated recent wild type mumps virus MuVi/Zagreb.HRV/28.12 in Vero cells through 16 passages but already the fifth passage (p5) showed accumulation of DIPs and attenuated neurovirulence in a newborn rat model when compared to the second passage (p2).

A possible role of C5a in activation of other plasma cascade system was shown in a rat model when C5a antibodies ameliorated impairment of the coagulation and fibrinolytic system.

In fact, in our laboratory, where LF production is a routine and frequently performed procedure, we have on rare occasions obtained preparations of LF that produce much higher TTD in the uniquely sensitive Fischer rat model when compared to previously validated standard LF preparations.

Importantly, IL-15 has previously been shown to reduce both blood pressure and the heart rate in a rat model when administered both locally and systemically, despite contraction of A1 and A2 arterioles [ 12].

The activity was also demonstrated in vivo using a rat infection model; when coated and uncoated Ti-wires were implanted into subcutaneous pockets of the rat and were challenged with 10 CFU of Staphylococcus aureus under a 7-day implantation period, CFU was decreased by 85% for treated rats compared to controls [ 18].

The present results are perfectly supported by our revolutionary findings obtained in the adjuvant arthritis rat model 10 years ago, when we described a potent protective function of capsaicin-sensitive afferents via somatostatin release (Helyes et al., 2004).

Optimized indole GSM 29 exhibited good alignment of in vitro potency and physicochemical properties, and moderate reduction of brain Aβ42 was achieved in a rat efficacy model when dosed orally at 30 mg/kg.

Expression of a dimeric chimeric human TNFR1 IgG fusion protein from adenovirus was effective in a rat CIA model when delivered intravenously after onset (low level) of disease, but it was ineffective when delivered intra-articularly [ 43].

Ethyl pyruvate, a pyruvate derivative that prevents mortality in murine sepsis models, reduced motor impairments, neurologic deficits, and infarct volume in a rat stroke model when given as late as 12 hours after middle cerebral artery occlusion [ 104].

D-penicillamine and auranofin were also reported to inhibit T cell proliferation [ 20, 21], but had no inhibitory effects on a rat AIA model when administered after the onset of arthritis [ 22].

Translating these findings in vivo, we evaluated therapeutic effect of 3,4,6-O-Bu3GalNAc 3,4,6-O-Bu3GalNAc 3,4,6-O-Bu3GalNAcA when delivered via lonal inthe-aratcular sustained-release delivery using modelparticles and fofnd this method to be efficacious in posttraumatic prOAression.