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The pharmacokinetic and pharmacodynamic properties of SPI-1865 were assessed in mouse and rat model systems.
Recent research findings suggest that physiologic amounts of supplemental dietary boron (PSB) affect a wide range of metabolic parameters in the chick and rat model systems.
For this work, we used causal edges derived only from published experiments performed in human, mouse, and rat model systems, both in vitro and in vivo.
Numerous studies have demonstrated the efficacy of Se-methylselenocysteine (MeSeCys) in preventing mammary cancer in rat model systems [ 16, 19- 23], and importantly, MeSeCys has been shown to be twice as active as Se-methionine (the primary component of Se-yeast supplements) in preventing the development of mammary tumors in rats [ 18].
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We have previously reported duration-dependent changes in retinal vascular permeability, apoptosis, and mRNA expression with diabetes in a rat model system.
Finally, our findings may widen the scope for future studies of decision-making mechanisms in the context of social interactions [41], [42] using the rat model system.
In the rat model system, elevated levels of CO3 were shown to be critical for de novo lipogenesis and these have been associated with liver lipodystrophy observed during myo-inositol deficiency [65], [66].
Also, successful making of transgenic rats for the neuroscience studies should also further enhance the experimental value of the rat model system from which a vast amount of neuropharmacological and behavioral data have been accumulated historically and facilitate the multi-level data comparisons [25], [26], [27], [28].
[ 6] in a rat model system.
This finding is supported by results from an experimental rat model system for radiation-associated mammary carcinogenesis [ 7].
Charman and Stella studied the lymphatic transport of DDT (log P, 6.19) and hexachlorobenzene (log P, 6.53) in an in situ rat model system.
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