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Interestingly, elevated levels of miR-34a contribute to osteoarthritis, since silencing of miR-34a in an osteoarthritis rat model resulted in reduced cartilage destruction (Abouheif et al. 2010).
A previous study designed to analyze the prebiotic effect of sorbitol in a rat model, resulted in the isolation of five Lactobacillus strains from the intestinal content that could not be assigned conclusively to known species [ 29].
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The use of human donor RBCs in a rat transfusion model resulted in clearance from cells from the circulation.
The use of human donor RBCs in a rat transfusion model resulted in clearance from cells from the circulation, associated with the presence of donor cells in all organs.
The optimized rat tibial fracture model resulted in mainly transverse tibial mid-shaft fractures with minimal bone comminution and absence of surrounding soft tissue damage.
The initial depletion of CD8-positive cells in our syngeneic rat colon carcinoma model resulted in a higher frequency of animals developing metastases.
Dopamine conjugated on the surface of chitosan nanoparticle administered in rat model has resulted in less cytotoxic long-term release than dopamine alone.
Subcutaneous injection of the materials were well tolerated in a rat model and resulted in elimination of the material progressively over 3 months while showing good biocompatibility on histology.
Over-expression of LOX in a rat dermal wound healing model resulted in significantly enhanced mechanical strength of the wound site, indicating increased cross-linking of the extracellular matrix[31].
Application of Cellufine sulfate as adsorbent for HMGB1 in rat hemoperfusion models resulted in decreased HMGB1 serum levels and improved survival in rats with ischemia-reperfusion injury [ 28, 29].
Administration of AMG 416 by IV bolus injection into rats with acute renal dysfunction (1K1C model) resulted in a sustained reduction in plasma PTH from the initial elevated values.
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