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Finally, the FRD rat model represents a valuable experimental tool to study the effect of agents potentially able to prevent or attenuate the vascular pathology associated with the MS and type 2 diabetes.
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The results described above using the A β1-42-injected rat model represent correlated data between extents of microgliosis and viability of neurons.
Our experiments show that as IL-10 down-regulates the production of proinflammatory cytokines, the higher IL-10 levels were observed in obese type 2 diabetic rat models represent an attempt to inhibit continued proinflammatory cytokine production.
The paw swelling in AA rat model also represents the severity of arthritis.
To investigate the molecular and cellular pathogenesis underlying myocarditis, we used an experimental autoimmune myocarditis (EAM -induced hEAM -induced rat model theartepresents T cell mediated postinfailureoratheart disorders.
Advantages of a rat versus a mouse model include its size and evidence that the rat model may represent the human disease processes better than the mouse equivalent (Oyasu, 1995).
The 2013 model represents year two.
This model represents an essential first step.
The genetic dissection of a rat model for MS represents such an approach, with the assumption that there are conserved mechanisms regulating neuroinflammation among species.
These differences may reflect stages in disease progression in individual animals, with the larger responses (also seen in the GK rat model [ 8]) representing an early stage of compensatory upregulation of responsiveness.
Using the rat model, the present study demonstrates some limitations.
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