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Furthermore, the current rat model mimics human PD better than our own mouse model [18] in several aspects such as death of SN neurons and formation of Lewy body-like aggregations.
The low-dose MIA induced OA rat model mimics the human disease condition and clearly demonstrates disease progression in the tibial subchondral bone in a timely manner.
Despite some biological differences with respect to humans, as discussed in the review of Elovitz and Mrinalini (2004), our rat model mimics the situation of preterm neonates who must complete their neurodevelopment without a maternal TH supply.
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The GL-induced peak and timing of glycogen increase in the muscle are also consistent with previous studies5,6,7,8, indicating the physiological validity of our rat model mimicking human GL.
In a rat model mimicking chronic ocular hypertension, the authors found that Aβ colocalized with apoptotic RGCs [ 16].
We have used a rat model mimicking the conditions of subjects working in shifts or permanently living at high altitude.
Materials and methods We designed a rat study to investigate lithium-induced encephalopathy and correlate its severity to plasma, erythrocyte, cerebrospinal fluid and brain lithium concentrations previously determined in rat models mimicking human poisoning patterns.
In the present study we characterized the etiology of VDT-associated dry eye by epidemiological study of VDT users and investigated the underlying mechanism and precautions by a rat model that mimics the condition of VDT users.
These findings demonstrate that the low-dose MIA rat model closely mimics the pathological features of progressive human OA.
Whether this indicates that this 'late onset' transgenic HD rat model rather mimics early stage HD or displays a different pathological process remains to be elucidated.
In order to improve our understanding of duration-dependent effects of the ICU intervention on molecular and functional networks that control the muscle wasting and weakness, we have used a unique experimental rat model that mimics the ICU condition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com