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Our asphyxia cardiac arrest (ACA) rat model is well established.
Notwithstanding, the pithed rat model is predictive of (cardio vascular side effects [11, 12] and provides information that cannot be obtained from in vitro studies [32].
The pithed rat model is a useful preparation for investigating the cardiovascular (side) effects of new developed antimigraine drugs (i.e. isometheptene enantiomers) and their mechanism of action.
Conclusion: The degree of post-CEA intimal hyperplasia in a rat model is directly related to the plasma level of homocysteine.
The pithed rat model is appropriate to assess peripheral cardiovascular effects, however, it should be kept in mind that it excludes central nervous system mechanisms, which might be relevant in the clinical situation.
Our study suggests the rat model is not appropriate for the investigation of bacteria responsive colon-targeted beads probably due to the important anatomical and physiological differences between human and rat gastrointestinal tracts.
In this study, an ovariectomized (OVX) Wistar rat model is applied to evaluate the effects of SDCP on biochemical bone turnover markers relative to its effects on bone mass.
The reason why glutamine is not significantly increased in the female tumour group in our rat model is unknown and deserves future studies taking also into account that gender differences have been reported in healthy subjects in some brain areas [55].
The rat model is validated by similar findings in human tissue.
Thus the concomitant loss of DARPP32 and β-Gal in the present rat model is consistent with neurodegeneration (i.e. dysfunction and suffering) possibly without the actual disappearance of the striatal neurons.
Although successful use of naked siRNA targeting the pain-related cation channel P2X3 to treat chronic neuropathic pain in a rat model is reported [37], poor uptake by brain parenchymal cells was shown in other studies [38], [39].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com