Possible beneficial effects of incorporating growth factors into the socket of a replanted molar in the rat model include improved pulpal vascularisation with the use of EGF and improved pulp cell organisation with NGF.
The marked characteristics of diabetic rat model include weight loss, increase food and water intake, and bradycardia.
Common functional deficits following in utero alcohol exposure in mouse and rat models include cell proliferation, differentiation and apoptosis, affecting tissue growth and remodeling and specifically neuronal growth and survival.
Nevertheless, there are some similarities with the rat TNBS model, including increases in Chi3l1, Mmp3, 10 and 12, Apoe, S100a8, Ltb, Sod2, Cxcl1, Cxcl2, Il6 and many other genes.
For these reasons, a comprehensive reversibility experiment using a rat model and including quantitative measures of ROM over a time course would provide the rationale to improve the management of joint contractures.
Furthermore, ASE prevented chronic pain in a rat spinal nerve ligation model, including thermal hyperalgesia and mechanical allodynia.
In addition to Crabp2, other components of the retinoid signalling pathway were found to be significantly elevated in the joints of the aforementioned rat OA joint instability model, including genes encoding proteins involved in retinoic acid synthesis (Aldh1a3) and retinol transport and delivery (Lrat and retinol dehydrogenase) and a putative retinoic acid target gene (Stra3) [ 30].
In the Zucker obese rats, a homeostasis model includes assessment-insulin resistance index, rosuvastatin treatment improved albuminuria, podocyte foot process effacement, and NADPH oxidase activity via superoxide dismutase [ 67].
Advantages of a rat versus a mouse model include its size and evidence that the rat model may represent the human disease processes better than the mouse equivalent (Oyasu, 1995).
In this study we present a comprehensive, longitudinal evaluation of OA pathogenesis in a rat model of OA, including histologic and biochemical analyses of articular cartilage degradation and assessment of subchondral bone sclerosis.
