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Our results present the potential of inhibiting colon cancer in vitro and DMBA-induced tumor in rat model in vivo by liposomal celecoxib.
The study was aimed to illuminate the effect of chrysin in the pathogenesis of ammonium chloride (NH4Cl) induced hyperammonemic rat model in a dose dependent manner.
The therapeutic efficacy of the prepared nanospheres was assessed using the trinitrobenzenesulfonic acid (TNBS) colitis rat model, in comparison with conventional enteric microparticles.
Prior to its human clinical trials, its efficacy was tested in Zn induced HT Wistar rat model in the present study.
Thus, the present experiments were designed to explicitly control Tat and cocaine administration in an in vivo rat model in order to reconcile differences that exist in the literature to date.
The current study was designed to investigate potential causative mechanisms of this impairment by using a rat model in which presbycusis is inducible by administration of d-galactose (d-gal).
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At the seventh day after the diabetes rat models were prepared, the MSCs (5.0 × 106 cells/rat) labeled with QDs were injected into the rat models in the MSC treatment group via tail vein, while the normal control group rats received the same dose of QDs-labeled MSCs.
However, the use of rat models in mechanistic studies has been limited due to lack of genetically modified rat strains.
Lacosamide has also been analyzed in rat models in which pain is induced by systemic inflammation [ 13].
These can broadly be divided into rat models, in which elevated IOP is induced experimentally [ 33], and mouse models, where IOP elevation occurs spontaneously [ 18].
Here, we tested this hypothesis using in vitro and in vivo rat models in combination with viral gene transfer and optogenetic approaches.
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