Sentence examples for rat model expressing from inspiring English sources

We have previously shown that a transgenic rat model expressing misfolded truncated tau protein developed extensive neurofibrillary pathology.

Neuronal loss has, however, been reported in a rat model expressing both PS1 and APPsw (Cohen et al., 2013), indicating that some animal models might be more suitable at recapitulating the disease.

In conclusion, except for the mRNA levels of Bmp7 and Bmpr2, TDSCs isolated from the collagenase-induced patellar tendon injury rat model expressed higher mRNA and protein levels of BMPs (BMP-2, BMP-4, BMP-7) and BMP receptors (BMPR-IA, BMPR-IB, BMPR-II) compared to the TDSCs isolated from the healthy animals.

In contrast, similarly prepared rat models expressed transactive response deoxyribonucleic acid-binding protein 43 only in the nucleus of motoneurons.

Other APP tg rat models express mutant hAPP695 (K670N/M671L) under the control of the ubiquitin-C (UbC) promoter, which shows a similar ubiquitous expression pattern as the human APP promoter (Folkesson et al. 2007); (Agca et al. 2008).

In a previous study, we found a substantial correlation between radiolabeled somatostatin analog uptake in tumors, as determined by SPECT and DCE-MRI-derived tumor perfusion/permeability parameters in a preclinical rat pancreatic-tumor model expressing somatostatin receptors [22].

To answer this final question we used a transgenic rat model ubiquitously expressing human placental alkaline phosphatase (hPLAP) as a recipient of wild type cells [ 13, 14].

The best characterized GEMs have been created using the androgen-dependent probasin promoter to determine tissue specific transcription of SV40 oncogenes: the transgenic adenocarcinoma of the mouse prostate (TRAMP) model in which the transgene includes large and small T antigen early SV40 oncogenes [ 29] and the LADY and the TRAP rat models, which express only the large T antigen [ 30, 31].

In order to get a better understanding of the role of proliferation in cyst initiation we utilized a transgenic rat model that expresses a truncated form of PC-2.

We set out to investigate the early events that contribute to cyst initiation and formation in polycystic kidney disease, by using a previously described transgenic PKD2 1-7033) rat model that expresses a truncated form of the PKD2 protein, which lacks almost the entire C-terminal region [ 28].

To study the link between fetal and maternal biological clocks, we investigated the effects of cycles of maternal food availability on the rhythms of Per1 gene expression in the fetal suprachiasmatic nucleus (SCN) and liver using a transgenic rat model whose tissues express luciferase in vitro.