In two independent experiments, when rats received Fe-SP intraperitoneally, systemic toxicity at high concentrations (4.0 mg/Kg body weight) was not observed while treatment in an OC rat model revealed chemotherapeutic response even at low concentrations (of 0.5 1 mg/Kg body weight) including complete responses within 12 days of treatment [8].
The concentrations of homeopathic remedies in the above mentioned studies ranged from 1x, 4x, 12x, 5c, 6c up to 1 M. Homeopathic remedies of Calendula and Hypericum applied were in the range of mother tincture (1x) in a rat model [ 33], but even Arnica 12x showed positive influence on wound healing in rats [ 32].
As for how this study relates to human newborns, Charles Berde, a professor of pediatrics and anesthesiology at Harvard Medical School in Boston, says the rat pup is a "useful model," even though a few days in a rat's life correspond to months of development in a newborn human.
The present study was conducted to develop a metabolic syndrome rat model induced by the FDW even with the consumption of normal diet.
The main aim of this study was to establish a metabolic syndrome rat model by consumption of FDW even with the consumption of normal diet.
Finally, it was recently shown that lisinopril not only halted age-related podocyte loss in a rat model of spontaneous glomerular injury, but even increased the podocyte number compared with age-matched untreated animals [ 97].
In STZ-induced type 1 diabetic rats, CAPA lowered plasma glucose levels even though this diabetic rat model has low insulin secretion activity, suggesting that insulin-independent mechanisms may be involved.
This conclusion is in line with experiments in the rat model that show a protective effect of hormones even after initiation by a chemical carcinogen.
In the combined rat model of VILI and acid aspiration, VT 3 ml/kg was more protective than 6 ml/kg, so even very low VT of 6 ml/kg can cause lung injury.
