Furthermore, we have validated the in vivo relevance of our engineered model tissues by comparing the changes in the expression levels of several key genes of the encapsulated CMs and iECs with in vivo rat MI model data and clinical data, respectively.
In addition, an additive effect of a combination therapy of upamostat with gemcitabine was observed in the mammary tumour rat model BN472 (WILEX AG, data on file).
The results described above using the A β1-42-injected rat model represent correlated data between extents of microgliosis and viability of neurons.
S. mutans strains NN2025 and UA159 are classified into the same serological group c, and show the same biochemical properties (e.g., fermentation of various sugars), adhesive properties to glass surfaces, and cariogenic properties in rat infection models (data not shown).
Teeguarden et al. (2005) parameterized this rat model using in vivo data from rats after BPA exposure with subsequent scaling to humans.
The rat model, in conjunction with data from monitoring Hg levels in human urine, feces, hair and blood over time have been used to develop a theoretical toxicokinetic model for predicting Hg distribution and elimination [ 24], however there are significant differences in the kinetics of Hg between rats and humans.
Here, we investigated whether the densities of OLs and OPCs were altered in cortical lesions of early and late-stage MS. Furthermore, we examined the efficacy of OPC and OL recruitment in cortical demyelinated lesions in a rat model of MS. Our data indicate that NogoA+ OLs as well as Olig2+ OPCs are substantially reduced in chronic, but not early cortical MS lesions.
Our data in rat model strongly support the theory that stem cells reside in the esophagus.
In addition, we find that hydrogen-rich saline can significantly improve the outcome and cardiac function in a rat model of septic shock (unpublished data).
Interestingly our data in the rat model were further corroborated by the analysis of clinical specimens of human brain at early and late time points post radiation.
