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This study was therefore designed to explore the effects of fenofibrate treatment in a VO rat model caused by severe aortic valve regurgitation (AR) with a focus on cardiac remodeling and myocardial metabolism.
In 1993, Tarpila and colleagues showed that acute pancreatitis in a rat model caused systemic bacterial colonisation [ 28].
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To our knowledge this is the first study reporting that BTZ-treatment in a rat model causes a general increase in the percent frequency of TRPV1- and CGRP-LI DRG neurons after both acute and chronic administration.
Hyperbaric oxygen (HBO) therapy, a process that is characterized by induced apoptosis, reduced vascular density and changes in gene expression, was shown to increase pO2 levels in a rat model causing significant reduction in tumor growth, by downregulating STAT3 and cyclin-D1 expressions.
PTDs have been employed for immunomodulation in experimental models of inflammation; for example, the delivery of the Tat-IκBα superrepressor in a rat pleurisy model caused a reduction in both leucocyte recruitment and production of proinflammatory cytokines [ 13].
Similar findings have been reported in the rat mesenteric artery, where CBD causes vasorelaxation with mid-micromolar potency, however, in the rat model CBD caused near maximal vasorelaxation.
Thus, pain associated with the rat OA model causes alterations in sleep architecture by disrupting the sleep pattern.
In a rat model, ncotine caused a change in the material properties of the supraspinatus tendon.
In OA-induced hyperuricemic rat model, hyperuricemia caused intrarenal oxidative stress, increased expression of NOX-4 subunit of renal NADPH oxidase and angiotensin II, and decreased NO bioavailability.
In our animal model, a chronic and steady compression is ipsilaterally applied to the DRG in rats (CCD model), causing the animals to show behaviors typical of mechanical allodynia ipisilaterally [24].
Here, we present LV gene expression profiling late (9 months) during the evolution of this eccentric hypertrophy model caused by severe aortic valve regurgitation in male Wistar rats.
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