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Studies in animal models, such as the Cohen diabetic rat, may also provide further insights into normoalbuminuric DKD, because in this model, urinary protein excretion does not increase with the development of diabetes despite decreasing creatinine clearance and typical changes of DN on renal biopsy (14).

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And those vexatious rats may also be on the way out.

The increased rates of escape failure (no escape responses) during this task that we found among JS rats may also imply an emotional disruption.

However, in all cases the fold changes in gene expression comparing the PTB and hypoxic experiments with regard to differentially expressed genes are small (Table 4), and it cannot be excluded that differences in pressure load comparing chronic hypoxic rats and PTB rats may also contribute to the differential gene regulation.

The prevalence in rats may also have been underestimated.

The experimental rats may also have disorders of the immune system that lead to fur loss.

Baseline high levels of oxidative stress and inflammation in SHHF rats may also increase their sensitivity to develop proliferative lesions.

These discrepancies suggest that differences seen here between CD1 mice and Wistar rats may also exist between different mouse and possibly rat strains.

In addition, the markedly enhanced urinary KIM-1u excretion) found in the same group of rats may also point to damage to PTC due to the SMV exposure.

The opposite effect of testosterone on Fmo3 in rats may also explain the reverse patterns of sex-dependent sensitivity to TCDD exposure.

The higher and more variable baseline levels of neutrophils in SH rats may also have obscured any modest CAP effects, and the time to necropsy may have been too short to induce the migration of neutrophils in the lung.

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