Sentence examples for rat lung development from inspiring English sources

Its expression is up-regulated in the late stage of rat lung development, but down-regulated in human NSCLC [21].

A number of miRNA profiling studies evaluating mouse and rat lung development have recently emerged and demonstrated the dynamic regulation of miRNAs during lung organogenesis.

As we found a significant association with two SNPs in the MMP16 gene, we further examined the expression of this enzyme during normal human and rat lung development, and in newborn rat models of arrested alveolar development.

Bhaskaran et al performed miRNA profiling at 7 time points in rat lung development using an in-house platform and identified 21 miRNAs in 4 clusters that showed significant changes in expression [20].

Further evaluation of MMP16 expression during the course of normal human and rat lung development showed relatively low expression during the canalicular and saccular stages and a clear increase in both mRNA and protein levels during the alveolar stage.

In this study we quantified mRNA expression of the surfactant protein genes and CC10 during normal rat lung development and prolonged exposure to hyperoxia with RT-PCR and followed the temporal and spatial distribution with in situ hybridization.

To conclude, PDE4 inhibition by rolipram displayed a potent inhibiting effect on hyperoxia-induced lung inflammation and mortality, but the direct inhibiting effects of the molecule on rat pup growth and lung development do not allow one to conclude favourably about its possible protective effect towards impaired lung alveolarization.

In the embryonic rat lung, sphingomyelin and sphingosine levels increase during development and plateau at birth.

In this study, a novel rat lung slice methodology has been developed and applied to study drug uptake in lung tissue, and the mechanisms by which this occurs.

Our study is therefore the first to provide strong evidence of MMP16 participation in normal and abnormal lung development, in both newborn rats and premature infants.

To examine the effect of activating GABAA receptors in fetal lung development in vivo, timed-pregnant rats of day 18 gestation underwent an in utero surgery for the administration of GABAA receptor modulators into the fetuses.