Only probesets that had normalised expression intensity greater than 30 in at least 50% of the samples in each rat line were included for further analysis.
Unravelling the molecular basis of this rat model may help in our understanding of complex human neurodevelopmental disorders, since many of the characteristics of the APO-SUS rat line are also observed in schizophrenic patients (Ellenbroek and Cools 2002).
The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations.
Alcohol-preferring AA and alcohol-nonpreferring ANA rat lines were crossbred to form a F1 population from which the final F2 population was derived.
Multiple laboratory rat lines are available, including outbred, inbred, and genetically modified strains, however, no gene targeting could be obtained due to the difficulties to derive truly pluripotent cell lines [9].
The congenic rat lines were established and maintained in a facility approved by the Association for Assessment and Accreditation of Laboratory Animal Care, as previously published [ 13].
First, oncogene involvement and genome integration might play a role, because the M13 rat iPSC line was induced using integrating lentiviral vectors to deliver the four Yamanaka factors, including the oncogene c-Myc.
RINm5F, Rattus norvegicus (rat) cell line was obtained from the American Type Culture Collection (ATCC, Manassas, USA).
Growth factor activity which stimulates anchorage-independent growth (AIG) in a rat fibroblast line, was detected in human premalignant adenoma tissue from familial polyposis coli colectomy specimens and in serum-free culture supernatant from an adenoma cell line PC/AA.
Like MG-63 cells, proliferation of the ROS 17/2.8 rat osteosarcoma cell line was not affected by sequential deformations.
