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The expression of angiogenic factors VEGF and HIF-1α are reduced in the hearts of diabetic patients during acute coronary syndromes, and myocardial infarct size in the rat is increased because of a reduced expression of HIF-1α; therefore, poor collateral formation in diabetes may be attributed at least in part to weaker bone marrow stimulation from the ischemic tissue.
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Fig. 7A shows that the random migration capability of early passage VSMC from old rats is increased 1.9 fold compared to that of young VSMC (p<0.05).
It has been reported [16] that liver cytochrome oxidase (Complex IV) activity in rats is increased with short-term (25 weeks) and decreased with long-term (60 weeks) consumption of fish oil.
In contrast to humans, the renal perfusion in BDL rats is increased, despite decreased creatinine and sodium excretion [ 158, 159].
Expression of β-galactosidase in the Tibialis anterior muscle of Sprague Dawley male rats was increased 250-fold by GET42 compared to DNA injection alone.
The bioavailability of oxymatrine in rats was increased remarkably after oral administration of OMT PLC (p < 0.05), compared with those of oxymatrine or the physical mixture.
AhR protein in rats was increased by VCD dosing in oocyte nuclei in primordial and primary follicles when measured by immunofluorescence and confocal microscopy.
In addition, the activities of lysosomal enzymes (beta-glucuronidase, beta-N-acetylglucosaminidase, and cathepsin-d) in the serum and heart of ISO rats were increased significantly.
The basal plasma concentrations of glucagon in young GK rats were increased.
Expression levels of LC3-II and caspase-3 cleavage product in the articular chondrocytes of 21- and 30-month-old rats were increased compared to their 6-month-old counterparts (Figure S4).
In addition, the frequency of mIPSCs from adult rats was increased (Inter-event interval: Control: 52.39±1.67 ms, TTX: 32.86±0.32 ms; Fig 4B; control: n = 11, 4 animals; TTX: n = 8, 4 animals).
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