OVX rats also showed a significant increase in plasma NTx levels compared to Sham rats indicating increased bone resorption.
In the current study, plasma ALP was significantly increased in OVX rats compared to SHAM rats, indicating increased osteoblastic activity with increased bone formation.
In the current study, malondialdehyde (MDA) was significantly increased in the ovariectomized rats indicating increased oxidative stress in these estrogen-deficient rats.
At 40 weeks, the level of cleaved caspase-3 was increased in the glomeruli of the obese rats, indicating increased glomerular apoptosis.
Exposure to concentrated ambient particles (CAPs; median, 182.75 μg/m) for 5 hr/day for 3 days decreased the lumen:wall area ratio of small pulmonary arteries in rats, indicating increased pulmonary vascular resistance (Batalha et al. 2002).
Rises in PINP serum levels of up to 52% in BDL rats, indicating increases in type I collagen formation, were shown to be correlated with the extent of liver fibrosis (R2 = 0.42, P < 0.001).
Mitochondria from high fat-fed rat hearts had lower ADP/O ratios than controls, indicating increased respiratory uncoupling, which was ameliorated by GDP, a UCP3 inhibitor.
Moreover, tibias of OVX rats showed eroded cavities with widened bone marrow spaces indicating increased bone resorption.
In addition, sleep efficiency was found to be augmented indicating increased sleepiness during the four first days in the lesioned rats.
Recently, the investigation on effects of prenatal and postnatal lead exposure on monoamine oxidase (MAO) activity in the different stages of rat brain development has indicated increased MAO activity in most of the brain regions especially at early developmental stages (2 weeks of age) and the toxicity was gradually decreased with the development of rats.
