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A phylogenetic tree of CYP2C amino acid sequences from human, cynomolgus monkey, rhesus monkey, dog, and rat indicated that CYP2C93 is orthologous between cynomolgus monkey and rhesus monkey, but does not have a 1-to-1 relationship to human CYP2C (Fig. 2).
A study conducted in the rat indicated that estradiol causes reduction in ER message and protein in vivo and in vitro in the pituitary [ 14], which is contrary to our observations.
Studies in the rat indicated that exposure to doses of 1/6 and 1/12 of the LD50 per day of DEHP resulted in a reduced gain in body weight compared to controls.
Another sciatic nerve injury model study in the rat indicated that, after a low-frequency pulsed magnetic field therapy for 38 days, the Wallerian degeneration as well as the electrophysiological assessments remained comparable between the group receiving the pulsed magnetic field treatment and control group [ 23].
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Evidence that p300 might be important in the intestines has been reported, with mRNA analysis in the rat indicating that p300 is expressed in excess of CBP.
The resulting plots are highly correlated for both mouse and rat, indicating that indeed the two array studies generated highly similar results.
Evidence from RCS rats indicates that failure of RPE cells to phagocytose outer segments results in reduced lipofuscin levels [ 40].
Statistical tests show that Ka/Ks is significantly less than 1 on branches leading to bushbaby, lemur, treeshrew, dog, mouse, and rat, indicating that purifying selection acted for much or all of these species' histories.
They were reminiscent of the functional enrichment results previously reported in CNV genes of human, mouse and rat, indicating that the bias towards these functional categories might be a common overall characteristic of CNV genes [19], [21], [30].
Moreover, the behavioral features of the WKY/NCrl rat indicate that it should be a useful model for ADHD-PI, the primarily inattentive subtype of ADHD.
On the other hand, pairwise comparisons of human with mouse and human with rat indicate that there are very limited regions of similarity in the PEDF promoter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com