The study design consisted of two groups of six rats in parallel: the rats of the control group received caffeine (3 or 10 mg/kg, i.v).v
It can be noted that the old rats showed a significantly lower level of erythromycin N-demethylase activity than the young rats, in parallel to a decrease in GSH, GSHPx and ATP, and an increase in TBARS.
Cyp2e1 is of particular interest in that protein levels increase in pancreas, liver, kidney and brain of type 1 diabetic rats in parallel to reactive oxygen species production and lipid peroxidation; furthermore overexpression of Cyp2e1 augments both glutathione S-transferase A4-4 levels and mitochondrial reactive oxygen species [61].
Braidy et al. [ 56] observed decreased SIRT1 activity in the heart, liver and kidneys of 12-month-old Wistar rats in parallel with decreased levels of NAD+, compared with 3-month-old rats.
Although no expression changes were apparent in SH rats after DE exposure, determining expression profiles for these rats in parallel to WKY provided novel insights into the potential mechanism of cardiac DE effects.
For group B rats, human pathogenic E. coli were fed to rat animals in parallel with administering specific coliphage cocktail in order to measure the potential of the phage master mix in controlling the externally inoculated pathogenic E. coli as well as the resident E. coli flora of rats.
Diabetes also selectively reduces the expression of occludin in the diabetic rat retina in parallel with increased BRB permeability.
Therefore, to define a list of genes with general gender-dependent gene expression, transcriptional analysis was performed in three rat groups in parallel.
Sridharan et al. [ 16] recently demonstrated upregulation of ErbB signaling in the irradiated rat heart in parallel with developing cardiac fibrosis, leading to the suggestion that ErbB signaling and pro-survival pathways are activated in an attempt to regenerate the myocardium.
The courses of Kaplan-Meier curves of ENU-exposed BDIX and Mss1 rats run in parallel for 150 days; however, tumor development is delayed in Mss1 rats, and is no more seen in animals older than 260 days.
