Previous investigations in the rat have demonstrated that a single 1 μg injection of kainic acid directly into the ventral horn resulted in excitotoxic cell loss (Mitra et al., 2013).
In contrast, multiple antithyroid drugs administered to the rat have demonstrated an increase in thyroid tumors, including PTU, thionamides, and the hepatic enzyme inducer phenobarbital (PB) (Capen 1997; Hurley et al. 1998; McClain et al. 1988).
An experimental study in rats has demonstrated the protective role of nebivolol against CIN [ 190].
And study using diabetic rats has demonstrated that local administration of rhPDGF-BB could enhance the fracture healing [ 23].
Modern research in ovariectomized rats has demonstrated that the crude FLL extract could be useful to modulate the calcium balance and the turnover of bone [ 14– 16].
Moreover, taurine supplementation in rats has demonstrated to reduce neuronal and glial cell death in different pathological conditions (Zeng et al. 2009; Jammoul et al. 2009, 2010).
A preclinical study in diabetic rats has demonstrated that rosiglitazone prevents the loss of pancreatic β-cell mass by maintaining β-cell proliferation and preventing net β-cell death (31).
A 35-day toxicity study in rats has demonstrated that the dried ginger powder at the dosages of 500, 1000 and 2000 mg/kg (equivalent to 48 192 mg/kg ethanolic extract used in the present study) was not associated with any mortalities and abnormalities in general conditions, behavior, growth, food and water consumption, hematological and blood biochemical parameters [ 26].
Preliminary experiments in healthy rats have demonstrated the clear visualization of the myocardium and limited background activity using microSPECT/CT imaging.
Moreover, studies in rats have demonstrated that A. sativum can interact pharmacodynamically with antihyperlipidaemia and antihypertensive medicines, such as atorvastatin, propranolol, hydrochlorothiazide or captopril.
