VAD rats exhibited normal motor functioning, as evidenced by the lack of a significant difference in swimming speed [data not shown, F 3,35) = 1.32,p = 0.28].
At 8-week-old age, at which no significant differences in body weight were observed between neonatal SAL- and DEX-treated rats, DEX-treated rats exhibited normal hippocampal synaptic plasticity and contextual fear memory performance compared with SAL-treated rats [9].
Following SNL surgery, rats exhibited normal grooming behaviour and weight gain similar to sham-operated controls.
The sham-operated rats exhibited normal neurons with well-structured, closely-arranged, clear and intact cellular form.
Furthermore, OB rats exhibited normal serum TNF-α and insulin-like growth factor 1 (IGF-1) levels, with significantly elevated leptin levels (Table 1).
The findings from the histopathological analyses revealed that while the pancreatic tissues of the control rats exhibited normal islets, those of the alloxan-induced diabetic rats showed clear atrophy of β-Cells.
radiatum, elicited by single pulse stimulation (30 µA, 0.03 ms) of the apical CA3 commissural-associational projections, in slices prepared from colchicine-treated rats, exhibited normal-appearing waveforms (Fig. 4C), although response amplitudes (0.68±0.16 mV; n = 4 slices from 4 animals) were below those of slices from naïve animals (0.96±0.19; n = 3 slices from 3 animals).
On the other hand, control rats and STZ-diabetic rats treated with insulin exhibited normal weight gain and blood glucose levels.
Freezing behavior during each session is shown in Figure 2. As we have previously reported [14], [15], rats receiving immediate extinction exhibited normal short-term fear suppression but recovered this fear the following day.
For instance, Bevacizumab, a humanized mAb against VEGF, with a pI of 8.2 due to kI/VH3 scaffold, exhibited normal PK in rats whereas the aforementioned anti-HCV mAb, with pI of 8.2 with the same framework, exhibited poor PK (Li et al., 2014).
