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In contrast to that, in a recent publication, we demonstrated that primary tubular epithelial cells from a 7.5-week old PKD2 mutant 1-7033) tratsgenic rat, display increased proliferation accompanied by alterations in expression of Cdk2 and p57, but independent of p21 [ 26].
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Hypothyroid rats display increased caspase 3 activity and increased levels of pro-apoptotic Bcl2 members and decreased Bcl2 family members in the cortex [7] cerebellum [8], and hippocampus [9].
Whole body metabolic characterization shows that old rats display increased body weight and lipids, while protein mass is significantly lower.
Differences in the metabolic responses of rodents fed a HFD vs. "cafeteria" Western diet have been previously noted, although both dietary challenges can induce obesity and hepatosteatosis, cafeteria-fed rats display increased inflammation in fat and liver tissue (32).
Fig. 1c shows that islets isolated from GK rats displayed increased ncNOS activity.
Adolescent rats displayed increased behavioral despair in the forced swim test, which was not seen in adult fluoxetine treated rats.
Swerdlow et al. [ 33] reported that Sprague-Dawley rats displayed increased disruption of PPI responses by apomorphine, a dopaminergic agonist, when compared to Long Evans rats.
The post-hoc comparisons indicated that the S4/L7 rats displayed increased startle responses when compared to S4/S7 rats (LSD, p < 0.04).
In our previous study, hippocampal CA1 neurons of BMAA-treated rats displayed increased staining for both ubiquitin and α-synuclein compared with controls (Karlsson et al. 2012).
The livers of aged rats displayed increased levels of the premature form of IL-1β as well as increased levels of the activated form of IL-1β (Fig. 3C).
However, plantaris muscles from TB-FO rats displayed increased relative percentages of MHC type I (8.2 ± 0.3% vs. 2.9 ± 0.9%, respectively) and decreased relative percentages of MHC type IIb (39.7 ± 1.6% vs. 51.6 ± 1.8%, respectively) compared plantaris muscles from sham-operated TB rats (p ≤ 0.05).
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