Naked mole-rat differences in cancer susceptibility are attributed to greatly enhanced stringency for proliferative control (e.g., p53, pRb, and the Ras/MAPK pathway) and over-expression of genes both encoding products that protect DNA during transcription and promote xenobiotic detoxification [ 76- 79].
In rats, differences in postnatal growth restriction leads to changes in development and in insulin sensitivity.
In comparison to cLH and cNLH rats, differences in response times between rats with or without previous shock exposure seemed to be less prominent over the course of LH testing.
In comparison to other studies, using this same stress model in rats, differences in the startle amplitude response (2.5 to 2.2 fold higher) seen between PSS+PL versus UNEX+PL or UNEX+BA, respectively, was consistent with the 2.5-fold increase previously reported by Cohen et al. (2004).
Kervran et al. (1978) concluded that the differences between the human's clinical findings and the experimental results using rats are due to the short pregnancy time in the rat and differences in the percentages of adipose tissue in rat fetuses (1%) and human offspring (16%) and the greater weight gain in the human species.
Only male rats were selected for this study because female rats have differences in reproductive hormones throughout their ovulatory cycle that could affect glucose metabolism (Gustavsson et al., 2011).
Testing of the anti-hsp65 antibody response in naïve LEW rats, naïve BN rats and arthritic LEW rats revealed important differences in AA-susceptible rat strains versus AA-resistant rat strains [ 23].
FSL/FRL rats were generated as a result of selective breeding of out-bred Sprague-Dawley rats for differences in the effects of the anticholinesterase agent diisopropylfluorophosphate (DFP) [23].
In rats, individual differences in vulnerability to self-administration of drugs of abuse can be predicted by individual locomotor responses to a novel environment.
The one-day version of the Morris water maze (MWM) test [Frick, K.M., Stillner, E.T., Berger-Sweeney, J., 2000. Mice are not little rats: species differences in a one-day water maze task.
