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In this model, the rat develops a full-blown cancer by day 4 and survives only for 7 days.
Ask yourself if you can afford the cost of surgery if your rat develops a lump that needs removal.
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"I know of one scientist who in 1996 was working, with rats, developing a drug that would cause regeneration in the central nervous system," he says.
Following injury, rats developed a bilateral persistent hypersensitivity to mechanical stimulation in the territory innervated by the infraorbital nerve.
Diabetic rats developed a sustained decrease in withdrawal threshold response to the von Frey test within 8 weeks after a single injection of STZ (45 mg/kg, i.v).v
Under conditions where the lung uf-TiO(2) burdens were equivalent, rats developed a more severe inflammatory response than mice and, subsequently, developed progressive epithelial and fibroproliferative changes.
Under conditions in which the lung p-TiO(2) burdens were similar and likely to induce pulmonary overload, rats developed a more severe and persistent pulmonary inflammatory response than either mice or hamsters.
Consequently, the rats developed a metabolic dysfunction resembling prediabetes.
Both Tp53 Δ11/+ and Tp53 Δ11/Δ11 rats developed a wide spectrum of tumors, most commonly sarcomas.
In addition, male rats develop a greater tolerance to and dependency upon opiate drugs [ 4].
Zucker rats developed a significant dyslipidemia reflected by a pronounced hypertriglyceridemia and hypercholesterolemia as compared to the lean (Fig. 2).
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