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Our results in the E17.5 rat (corresponding to the E15.5 mouse) were similar to that reported in Wang et al. (Wang et al., 2009).
It is worth noting that these authors designate the obex as the caudal end of the area postrema in the rat, corresponding to the tip of the calamus scriptorius.
Globally, a minimal number of hepatic gene expression changes were observed (1023 probe sets with a fold change ≥ ±2.0 and p ≤ 0.01 for at least one rat, corresponding to approximately 3.3% of the array).
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The Western blots analysis was carried out with pool materials of 1 2 placentas and 1 2 kidneys from 5 rats corresponding to each experimental condition.
We analyzed a public dataset GSE13271 [42], currently the only GK/Wistar differential expression dataset in NCBI GEO, and identified 30 sets of differentially expressed genes (DEGs) between GK and Wistar rats corresponding to different tissues, time points, and feeding conditions.
The total cell population was calculated as the mean population of the six rats corresponding to each time point.
The average flow rate through the implanted tubes was 81·5 ± 2·2 μl/min (mean ± SE, n = 47 rats), corresponding to a wall shear stress of approximately 5 dynes/cm.
However, one has to bear in mind, that during normal breathing only 15%% (measured in rats; corresponding to 7%% in humans) of the inhaled air reach the OE (Kelly et al. 2000) via the dorsal medial airflow pathway, while a larger proportion just passes the RE via the lateral/ventral airflow pathway (Morris et al. 1993).
In this model, the axon-sparing neurotoxin ibotenic acid is delivered into the hippocampus of 7-day-old rats corresponding to the second trimester human fetal brain development when environmental and genetic risk factors are implicated in seeding schizophrenia (Lipska, Jaskiw & Weinberger 1993; Weinberger 1999).
In this section, we compare the segmentation maps produced for the rat brain slice with a schematic of the rat brain corresponding to the coronal section ~4.16 mm from Bregma drawn based on the rat brain atlas (Paxinos and Watson, 2007).
Our objective was to study lithium pharmacokinetics in blood and brain in rat models corresponding to each human presentation.
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