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These studies show the rat is a very poor model for humans and toxicity in the rat cannot be extrapolated to humans.
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"The ferocious rats cannot be handled," Mr. Albert said.
This result suggests that the dramatic differences in hypothermia in HDS and LDS rats cannot be related to 5-HT1A receptor-mediated action on G proteins.
However, paradigms developed for rats cannot be assumed to transfer straightforwardly to mice; the behaviour of the two species differs in many respects.
We show that developmental plasticity of HPA and fear responses in rats cannot be explained by a linear single-factor model based on environment-dependent variation in active maternal care.
These results suggest that the D3 receptor does not mediate apomorphine-induced disruption of PPI in rats, however, given the findings that PD 128907 elicited a PPI-disruptive effect that was blocked by selective D3 antagonists, a role of D3 receptor in mediating PPI in rats cannot be ruled out.
As there normally exists sex differences in liver and kidney metabolism, the highly statistically significant disturbances in the function of these organs, seen between male and female rats, cannot be dismissed as biologically insignificant as has been proposed by others.
Therefore, the differences in social and neuroendocrine function between novelty-exposed and home-staying rats cannot be mediated by maternal individual differences.
Because we and others did not find the difference in maternal care between SAL- and DEX-treated groups [20], the somatic growth deficits observed in DEX-treated rats cannot be explained by the deleterious effects of child abuse or neglect.
Inferences of the incidence of pla-positive rats cannot be made because of low sample numbers and potential bias in capturing rats that had putative infections.
As a whole, the changes in water observed in the liver mitochondria of the brain tumorbearing rats cannot be attributed to the decrease in liver weight.
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CEO of Professional Science Editing for Scientists @ prosciediting.com