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The resulting vector stocks supported 2.2- to 5.0-fold targeted gene transfer to nigrostriatal neurons in the rat brain, compared to vector particles that contained wild-type (wt) gC.
The higher γ-secretase activity in membranes from embryonic rat brain is in line with the reported higher levels of transition state γ-secretase inhibitor binding in postnatal rat brain compared to adult [41].
Despite the size of the rat brain compared the human brain the use of a 7T magnet allowed us to distinguish specific brain nuclei but not sub-nuclei within that structure as seen with techniques such as c-fos and 2-deoxyglucose [36].
In addition, astrogliosis is also increased in peptide-injected rat brain compared with controls.
By revealing that the barrel cortex essentially contains a texture map, Garion et al. have identified a fundamental difference in how tactile (or touch) information is represented in the rat brain compared to visual and auditory information.
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By way of validation, data from the perfusion of 50?µM propranolol in the rat brain was compared with the model outputs.
In addition, [14C]phenylacetate uptake in the rat brain was compared by autoradiography with that of [14C]acetate following the injection of fluorocitrate, a selective glial toxin, into the brain.
Then, the pharmacokinetics of these candidate compounds in the rat brain were compared by ex vivo LC-MS/MS assays.
In rat brain, we compared brainstem, right and left cortical hemispheres as well as cerebellum.
Here we conclude that γ-secretase dependent ICD production is decreased in adult rat brain membranes compared to embryonic.
Indeed, a 2-fold increase in the expression of ceruloplasmin was observed in the preconditioned neonatal rat brain as compared with the normal control.
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