Therefore, the 3-month-old rat is equivalent to a 13-year-old human, the 6-month-old rat corresponds to a 26-year-old human.
Given that the average weight of the rat was 475 g, the amount of ETOH consumed by nondeprived rats was equivalent to 1.2 4 g/kg.
The AUCs in plasma concentration of Ibuprofen and a new compound, ER-1039, following single oral administration of these compounds as the O/W microemulsion to fasted rats were equivalent to that of solution administration or increased by nine and two times that of suspension administration, respectively.
We found that contrast sensitivities of optomotor responses in W-TChR2V4 rats were equivalent to wild-type rats, even when native photoreceptor cells were degenerated by continuous light exposure.
The treatment dose (3 g/kg) in rats was equivalent to the maximal clinical dose of RR in the Chinese pharmacopoeia (0.5 g/kg) [ 14, 15].
5– 8 For each experiment, rats were randomly grouped into four groups per strain (n = 15 rats per group); the body weights of rats were equivalent among groups at the start of the experiment.
19, 21 The vertebral compressive strength in bazedoxifene-treated ovariectomized rats was equivalent to or better than that in sham-operated animals and significantly better than that in vehicle-treated ovariectomized animals.
HE and LE rats were equivalent on every activity measure in every test condition (data shown in Online Resource 2), with a trend for longer exit latencies and less light-zone exploration for LE rats in the light dark test, in line with the weak (nonsignificant) negative correlation observed between light-zone exploration and post-extinction freezing.
Preclinical studies [ 43, 44] showed promising anti-mammary tumor activity in mouse (~3.5 mg/20 g mouse · d) and rat models (~13 mg/275 g rat · d) that are equivalent to the effective concentration in humans (~2.8 g CLA/70 kg · d).
The age of the animals in our study (3 4 months) is a potential limitation given that rats of this age are equivalent to young adult humans – a population that rarely suffers from ischemic stroke.
