These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.
Compound 13c possesses good oral and intravenous pharmacokinetics in the rat and dog.
Moreover, 24 possessed highly encouraging rat and dog pharmacokinetic profiles with excellent oral bioavailabilities in both species.
Despite good activity against 5-HT6 receptor, 3a exhibited poor liver microsome stability in mouse, rat and dog.
Novel antagonists incorporating α-hydroxy amides were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and good bioavailability in the rat and dog.
In addition, the metabolic pathway of eprinomectin using cat liver microsomes, and plasma protein binding using cat, rat, and dog plasma were studied in vitro.
Contractions predominate on the primate, rat, and dog branches.
Genomic DNAs were extracted from human, rat, and dog liver specimens using DNasesy Kit (Qiagen).
We required the seed region to be conserved among human, mouse, rat, and dog genomes.
Only conserved binding sites (conserved in mouse, human, rat and dog) were considered.
We focused on analyzing several representative species, including human, rat, and dog.
