Our objective was to investigate possible synergy of MDPV/4MMC combination on their stimulant effects in the Sprague Dawley rat and analyze their mechanisms of interaction.
These skin substitutes were transplanted for 5 weeks on the backs of immuno-incompetent rats and analyzed.
To study the role of claudins in saliva secretion, we examined alterations in the expression patterns of cell adhesion molecules in parotid glands of γ-irradiated rats and analyzed the influence of those changes on intercellular barrier function using primary cultures of parotid acinar cells.
We passively transferred the IgG fraction intrathecally into rats and analyzed the effects using behavioral and in vivo electrophysiological methods.
To define the biodistribution of P-Dex, conjugates with different imaging labels were given to AA rats and analyzed.
Z.D. performed the in vivo studies in rats and analyzed the results with J.B. and H.T.C. M.K. completed the pilot experiments on human and mouse osteoclasts.
In first experiments, we injected several different cytokines and chemokines (IL-1β, TNF-α, IFN-γ, CCL7, CX3CL1, CXCL1, CXCL2, and IL-6) into the striatum of juvenile Lewis rats, and analyzed the integrity of the BBB 18 24 hrs later, using rat IgG leakage into the CNS parenchyma as surrogate marker for barrier dysfunction.
To specifically address this question, we injected the cytokines interleukin-1 beta, tumor necrosis factor alpha, interleukin-6, interferon gamma and the chemokine CXCL2 into the striatum of NMO-IgG seropositive rats and analyzed the tissue 24 hours later by immunohistochemistry.
Further evidence indicating the differential phenotype of foreign body giant cells and osteoclast cells is provided by our previous studies [ 45, 46] in which we implanted particles of polyethylene or polymethylmethacrylate into soft tissues of rats and analyzed the phenotypic features of the elicited cells.
To determine whether CR can affect senescence entry and lifespan of normal human diploid fibroblasts in vitro, three independent normal human fibroblast cell lines were subpassaged in media supplemented with either 10 % CR rat serum or 10% AL rat serum, and analyzed until they reached senescence.
